install.packages("rpact")
packageVersion("rpact")Advanced group-sequential and adaptive confirmatory clinical trial designs, with R practicals using rpact
1 Purpose of this document
Materials for the CEN 2023 pre-conference course Advanced group-sequential and adaptive confirmatory clinical trial designs, with R practicals using rpact, held in Basel on 3rd September 2023 by Kaspar Rufibach, Marc Vandemeulebroecke, Gernot Wassmer, and Marcel Wolbers.
2 Agenda of the event
09:00-09:10: Welcome
09:10-09:50: Theory: Efficient use of interim analyses (Kaspar)
09:50-10:30: Introduction to rpact, part 1 (Gernot), exercises (Kaspar & all, ex 1)
10:30-11:00: Coffee break
11:00-11:40: Theory: Introduction adaptive trials & sample size re-calculation (Marc)
11:40-12:30: Introduction rpact, part 2 (Gernot), exercises (Marc & all, ex 2)
12:30-14:00: Lunch
14:00-15:30: Theory: Multi-arm multi-stage designs (Marcel & Kaspar)
15:30-16:00: Coffee break
16:00-17:00: Introduction rpact, part 3 (Gernot), exercises (Gernot & all, ex 3-5)
17:00-17:15: Teaser: What can we expect from ICH E20? (Uli & Frank)
17:15-17:30: Final Q&A
3 Preparation prior to the event
- Please download all the documents from this webpage: link to zip file.
- Install the latest version of rpact locally on your computer:
4 Documents
| Presenter | Title | Slides | Markdown accompanying slides |
|---|---|---|---|
| Kaspar Rufibach | Efficient use of futility and efficacy interim analyses in group-sequential designs | X | X |
| Marc Vandemeulebroecke | Introduction adaptive trials & sample size re-calculation | X | |
| Gernot Wassmer | Introduction to rpact | X | |
| Marcel Wolbers & Kaspar Rufibach | Multi-arm multi-stage designs (MAMS) | X | |
| Frank Bretz and Uli Burger | Adaptive trials: Some general considerations | X |
- Exercises: exercise markdown as zip file | html.
- Solutions: solution markdown as zip file | html.
- Download all files as .zip file.