Advanced group-sequential and adaptive confirmatory clinical trial designs, with R practicals using rpact

Purpose of this document

Materials for the BBS training Advanced group-sequential and adaptive confirmatory clinical trial designs, with R practicals using rpact, held in Basel on 13th September 2022 by Kaspar Rufibach, Marc Vandemeulebroecke, Gernot Wassmer, and Marcel Wolbers.

Documents

Presenter Title Slides Markdown accompanying slides
Kaspar Rufibach Efficient use of futility and efficacy interim analyses in group-sequential designs X X
Marc Vandemeulebroecke Introduction adaptive trials & sample size re-calculation X
Gernot Wassmer Introduction to rpact X
Gernot Wassmer Closed testing principle in adaptive trials X
Marcel Wolbers Multi-arm multi-stage designs X
Frank Bretz and Uli Burger Adaptive trials: Some general considerations X