Advanced group-sequential and adaptive confirmatory clinical trial designs, with R practicals using rpact

1 Purpose of this document

Materials for the BBS training Advanced group-sequential and adaptive confirmatory clinical trial designs, with R practicals using rpact, held in Basel on 13th September 2022 by Kaspar Rufibach, Marc Vandemeulebroecke, Gernot Wassmer, and Marcel Wolbers.

2 Documents

Presenter Title Slides Markdown accompanying slides
Kaspar Rufibach Efficient use of futility and efficacy interim analyses in group-sequential designs X X
Marc Vandemeulebroecke Introduction adaptive trials & sample size re-calculation X
Gernot Wassmer Introduction to rpact X
Gernot Wassmer Closed testing principle in adaptive trials X
Marcel Wolbers Multi-arm multi-stage designs X
Frank Bretz and Uli Burger Adaptive trials: Some general considerations X